发明名称 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HYPOXIC OR ISCHEMIC INJURY
摘要 Compositions and methods of treating or preventing disease or injury to a human patient or biological material undergoing ischemic or hypoxic conditions.
申请公布号 US2014228302(A1) 申请公布日期 2014.08.14
申请号 US201414173471 申请日期 2014.02.05
申请人 FRED HUTCHINSON CANCER RESEARCH CENTER 发明人 Ruan Fuqiang;Winter Edward A.;Deckwerth Thomas L.
分类号 C07C323/67;C07D209/48;C07C319/04;C07K7/64 主分类号 C07C323/67
代理机构 代理人
主权项 1. A compound represented by the following structure: wherein R1 and R2 are independently a branched or straight chain C1-10 alkyl; a branched or straight chain C1-10 alkyl substituted with —ONO2; or, a branched or straight chain C1-10 alkyl substituted with —OH; wherein R3 and R4 are independently a branched or straight chain C1-10 alkanediyl; wherein R5 and R6 are independently OH, an amino acid moiety, or, a straight or branched chain C1-10 amine substituted with —ONO2; wherein X and Y are independently C═O or SO2; and, wherein m is 3 or 4; Z is selected from H, CH3, and CH2CH3; or, a salt, ester, hydrate, solvate, or stereoisomer thereof, with the proviso that when m is 3, Z is H, X and Y are C═O, R3 and R4 are CH2, and R5 and R6 are OH, then R1 and R2 are not C1-10 alkyl.
地址 Seattle WA US