发明名称 |
SILK FIBROIN AND POLYETHYLENE GLYCOL-BASED BIOMATERIALS |
摘要 |
This invention relates to methods and compositions for preparation of silk-PEGs based biomaterials through crosslinking by chemically reacting active polyethylene glycols (PEGs) possessing different chemical groups (e.g., thiols and maleimides functionalized PEGs) that are additionally stabilized by the beta-sheet formation of silk fibroin. The crosslinked silk-PEGs biomaterials present strong adhesive properties, which are comparable to or better than the current leading PEG-based sealant, depending on the silk concentration in the silk-PEGs biomaterials. In addition, the silk-PEGs based biomaterials are cytocompatible, show decreased swelling behavior and longer degradation times, which make them suitable for hemostatic applications where the current available tissue sealant products can be contraindicated. |
申请公布号 |
EP2611473(A4) |
申请公布日期 |
2014.08.13 |
申请号 |
EP20110822680 |
申请日期 |
2011.09.01 |
申请人 |
TRUSTEES OF TUFTS COLLEGE |
发明人 |
KAPLAN, DAVID L.;SERBAN, MONICA A. |
分类号 |
A61L27/44;A61L24/00;A61L27/14;A61L27/22;A61L27/26;A61L27/38;A61L27/52;A61L27/54 |
主分类号 |
A61L27/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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