Pyrimidinyl-piperazines useful as D₃/D₂receptor ligands

摘要

The present invention relates to new dopamine D3 and D2 ligands of formula (I):;
wherein R1, R2 and Q are as described herein, and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates and/or polymorphs thereof. The invention also relates to processes for preparing the same, to compositions containing the same and to their use in the treatment and/or prevention of conditions which requires modulation of dopamine receptors.

主权项

1. A method of treating a condition selected from the group consisting of psychoses, drug abuse, cognitive impairment accompanying schizophrenia, mild-to-moderate cognitive deficits, dementia, attention deficit disorders, hyperactivity disorders, mania, bipolar disorder, paranoid and delusional disorders, Parkinson's disease, neuroleptic-induced parkinsonism, depression and depressive states, and autism, which comprises administering to a subject in need thereof an effective amount of a compound of formula (I)wherein
Q represents C1-4 alkyl, —NR3R4, phenyl, optionally substituted phenyl, 1-pyrrolidinyl, 1-piperidinyl, 4-R5-piperazin-1-yl or 4-morpholinyl group, R1 represents hydrogen or C1-4 alkyl group, R2 represents hydrogen or C1-4 alkyl group, R3 represents hydrogen, C1-4 alkyl group, phenyl or optionally substituted phenyl, R4 represents hydrogen, C1-4 alkyl group, phenyl or optionally substituted phenyl, R5 represents hydrogen or C1-4 alkyl group, and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts thereof.