发明名称 |
Apparatus and method for elemental analysis of particles by mass spectrometry |
摘要 |
An apparatus for elemental analysis of particles such as single cells or single beads by mass spectrometry is described. The apparatus includes means for particle introduction; means to vaporize, atomize and ionize elements associated with a particle; means to separate the ions according to their mass-to-charge ratio; means to detect the separated ions, means to digitize the output of the means to detect the ions; means to transfer and/or to process and/or record the data output of the means to digitize, having means to detect the presence of a particle in a mass spectrometer; and means to synchronize one of the means for ion detection, data digitization, transfer, processing and recording with the means to detect the presence of a particle. Methods and computer readable code implementing aspects of the apparatus, and for reducing the rates of data generation, digitization, transfer, processing and recording are also described. |
申请公布号 |
US8803079(B2) |
申请公布日期 |
2014.08.12 |
申请号 |
US201313900306 |
申请日期 |
2013.05.22 |
申请人 |
Fluidigm Canada Inc. |
发明人 |
Antonov Alexei;Bandura Dmitry Roman |
分类号 |
H01J49/26 |
主分类号 |
H01J49/26 |
代理机构 |
Senniger Powers LLP |
代理人 |
Senniger Powers LLP |
主权项 |
1. A mass spectrometer for elemental analysis of a particle, the mass spectrometer comprising:
a particle introduction system; an inductively-coupled plasma source positioned downstream of the particle introduction system, the inductively-coupled plasma source being configured to produce ions and light emission from staining elements associated with the particle; an ion mass-to-charge ratio analyzer positioned downstream of the inductively-coupled plasma source, the analyzer being configured to separate ions according to their mass-to-charge ratio; a main ion detector for detecting the separated ions and producing data output; a digitizer for digitizing the output; a data transfer channel for transferring the digitized data output; at least one of a data processor and a data recorder to receive the digitized data output; a particle presence detector in the mass spectrometer having an activation corresponding with the detection of the light emission of a particle to be analyzed in the mass spectrometer; and a synchronizer having an activation input from the particle presence detector and that synchronizes with a command output to at least one of the main ion detector, the digitizer, the data transfer channel, the data processor and the data recorder; wherein the particle presence detector in the mass spectrometer triggers the synchronizer. |
地址 |
Markham CA |