IMPLANTABLE INTERVERTEBRAL DISC DEVICES AND USES THEREOF

摘要

Provided herein are implantable intervertebral disc devices, and methods of making the same. For example, an implantable intervertebral disc device comprises an engineered annulus fibrosus (AF) scaffold that can mimic its native-like cross alignment of pores/channels within the AF region, and can be served as a scaffolding material for cell and matrix alignment. Accordingly, methods of treating a disease or disorder associated with degeneration of an intervertebral disc in a subject are also provided herein, e.g., by replacing the degenerated intervertebral disc of the subject with an implantable intervertebral disc device described herein.

主权项

1. An implantable intervertebral disc device comprising:
a silk-based toroidal disc scaffold, the toroidal disc scaffold comprising on its circumferential surface at least two concentric layers of laminar silk scaffold strips; wherein a first laminar silk scaffold strip comprises at least about 5% of its first porous structures substantially aligned at a predetermined angle to the bottom edge of the first laminar scaffold strip; wherein a second laminar silk scaffold strip circumferentially wraps around the first laminar silk scaffold strip in a manner such that the second laminar silk scaffold strip comprises at least about 5% of its second porous structures substantially aligned at an angle of about 20° to about 160° with respect to the aligned first porous structures.