发明名称 |
PRO-DRUG FORM (P2PDOX) OF THE HIGHLY POTENT 2-PYRROLINODOXORUBICIN CONJUGATED TO ANTIBODIES FOR TARGETED THERAPY OF CANCER |
摘要 |
Disclosed are methods, compositions and uses of conjugates of prodrug forms of 2-pyrrolinodoxorubicin (P2PDox) with antibodies or antigen-binding fragments thereof (ADCs), with targetable construct peptides or with other targeting molecules that are capable of delivering the P2PDox to a targeted cell, tissue or pathogen. Once delivered to the target cell, the ADC or peptide conjugate is internalized, a highly toxic 2-pyrrolinodoxorubicin (2-PDox) is released intracellularly. The P2PDox-peptide or ADC conjugates are of use to treat a wide variety of diseases, such as cancer, autoimmune disease or infectious disease. |
申请公布号 |
US2014219956(A1) |
申请公布日期 |
2014.08.07 |
申请号 |
US201414175089 |
申请日期 |
2014.02.07 |
申请人 |
Immunomedics, Inc. |
发明人 |
Govindan Serengulam V.;McBride William J.;Sathyanarayan Nalini;Mazza-Ferreira Christine;Goldenberg David M. |
分类号 |
C07K16/18;A61K31/704 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
1. A conjugate comprising:
a) pro-2-pyrrolinodoxorubicin (P2PDox); and b) an antibody, antigen-binding antibody fragment, targeting peptide, or non-antibody cell-targeting construct attached to the P2PDox. |
地址 |
Morris Plains NJ US |