Dual Specific Binding Proteins Having a Receptor Sequence

摘要

Engineered multispecific binding proteins that bind at least one ligand for a receptor are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.

主权项

1. A binding protein comprising a polypeptide chain, wherein the polypeptide chain comprises RD1-(X1)n-VDH-C-(X2)n or VDH-(X1)n-RD1-C-(X2)n,
wherein RD1 comprises a ligand-binding domain of a receptor; VDH is a heavy chain variable domain; C is a heavy chain constant domain; X1 is a linker with the proviso that it is not CH1; X2 is an Fc region; (X1)n is (X1)0 or (X1)1; (X2)n is (X2)0 or (X2)1; and wherein (a) RD1 comprises a protein domain selected from the group consisting of SEQ ID NO: 1-3; and (b) VDH comprises a sequence selected from the group consisting of SEQ ID NO: 4, 6 and 8.