| 发明名称 |
METHOD FOR IDENTIFYING MODULATORS OF HCV TRANSLATION OR REPLICATION INVOLVING THE NS5B POLYPEPTIDE AND A PSEUDOKNOT |
| 摘要 |
The invention relates to a method for identifying compounds that act as modulators of hepatitis C (HCV) translation and/or replication, and to compounds identified by this method, and their uses in medicine. The invention also relates to an RNA useful for identifying modulators of HCV translation and/or replication. The invention further relates to a method for producing a replication-competent HCV virus. |
| 申请公布号 |
US2014221460(A1) |
申请公布日期 |
2014.08.07 |
| 申请号 |
US201214239593 |
申请日期 |
2012.08.17 |
| 申请人 |
Evans David J.;Simmonds Peter |
发明人 |
Evans David J.;Simmonds Peter |
| 分类号 |
C12Q1/70;C12N15/113 |
主分类号 |
C12Q1/70 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for identifying a compound that modulates hepatitis virus C (HCV) translation and/or replication, said method comprising:
(a) contacting an RNA comprising the SL9266/PK pseudoknot or a variant thereof and a translatable reporter coding sequence with the compound in the presence of an NS5B polypeptide or a variant thereof; and (b) measuring translation of the reporter coding sequence. |
| 地址 |
Coventry GB |
