Defensin-like molecules as novel antimicrobial agents

摘要

Disclosed are methods of treating and/or preventing infections in mammals caused by microorganisms, by administering to a mammal a therapeutically effective amount of at least one defensin-like molecule, e.g., in a composition that includes such molecule. Also disclosed are the use of such defensin-like molecules for treating and/or preventing infections in mammals; and kits that may include such molecules, or compositions that include such molecules, as well as instructions for using such molecules to treat a mammal.

主权项

1. A method of treating infections in mammals caused by microorganisms, comprising administering to a mammal a therapeutically effective amount of
2-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-4,6-diphenyl-pyran-3-ylium wherein said microorganisms comprise one or more gram-positive bacteria selected from the group consisting of Staphylococcus, Streptococcus, and Enterococcus.