s-Triazine compounds, pharmaceutical compositions and methods of using the same

摘要

Novel s-triazine compounds are disclosed that have a formula represented by the following:;
L1, L2, L3, R1, R2, R3, R4, R5a, R5b, and R5c are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, where microbial infection is either a direct cause or a related condition.

主权项

1. A s-triazine compound having a formula: wherein L1 is a single bond, and L2 is C1-C4 alkylene; or L1 is C1-C4 alkylene, and L2 is a single bond or C1-C4 alkylene; L3 is selected from C2-C6 alkylene, C2-C6 alkenyl, and C2-C6 alkynyl; each of R1 and R2 is independently substituted or unsubstituted C1-C6 alkyl; or R1 and R2 may join together to form a 4-7 membered heterocycloalkyl; or R1 is H; and R2 is —C(═NH)—NH2; R3 is R4; or R3 is selected from substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl; R4 is substituted or unsubstituted each X is C or N; provided that no more than three Xs are N at one time; andthe X through which the R4 is attached to L1 or L2 is C;each Y is C or N; provided that no more than three Ys are N at one time; andthe Y through which the R4 is attached to L1 or L2 is C;R6 is H or substituted or unsubstituted C1-C6 alkyl; each R5a, R5b, or R5c is independently H or substituted or unsubstituted C1-C6 alkyl; or a pharmaceutically acceptable salt thereof; or stereoisomers, or tautomers thereof.