Therapeutic use of mucin glycans

摘要

A therapeutic formulation containing mucin glycans derived from one or a number of nutritionally appropriate sources is described.

主权项

1. An infant formula supplement comprising:
(i) mammalian mucin glycans released and isolated from the protein component of mammalian mucins purified to comprise less than 10% by weight protein, which mucin glycans are a heterogenous mixture of linear and branched oligosaccharides from about 2 to about 10 saccharide subunits in length, that selectively stimulate growth of desirable gut microorganisms comprising Bacteroides species, wherein the mucin glycans upregulate a set of polysaccharide utilization loci (PULs) in said Bacteroides species similar to those PULs upregulated in response to human milk oligosaccharides (HMO); and optionally (ii) at least one human milk oligosaccharide (HMO).