| 发明名称 | Methods of inhibiting photoreceptor apoptosis | ||
| 摘要 | The present invention provides methods to prevent photoreceptor death. In particular, the present invention provides peptides which prevent FAS-mediated photoreceptor apoptosis. | ||
| 申请公布号 | US8796223(B2) | 申请公布日期 | 2014.08.05 |
| 申请号 | US201313691074 | 申请日期 | 2013.01.08 |
| 申请人 | The Regents of The University of Michigan | 发明人 | Zacks David Noam |
| 分类号 | A61P27/02;A61K38/10;C07K7/08;C07K14/82 | 主分类号 | A61P27/02 |
| 代理机构 | Casimir Jones, S.C. | 代理人 | Staple David W.;Casimir Jones, S.C. |
| 主权项 | 1. A method of inhibiting photoreceptor apoptosis comprising administering to a subject a photoreceptor protective composition comprising a photoreceptor protective polypeptide comprising: a) a fragment of MET comprising SEQ ID NO:1(MET12), or (b) a fragment of MET that comprises at least 70% sequence similarity to MET12, wherein said polypeptide inhibits FAS-mediated photoreceptor apoptosis, and wherein said photoreceptor protective composition is administered to said subject intraocularly, intravitrealy, or periocularly. | ||
| 地址 | Ann Arbor MI US | ||