| 发明名称 |
Identity Elucidation of Unknown Metabolites |
| 摘要 |
A method of elucidating the identity of an unknown metabolite comprising measuring amounts of known and unknown metabolites in subjects; associating the unknown metabolite with a specific gene from a gene association study; determining a protein associated with the specific gene and analyzing information for the protein; associating the unknown metabolite with concentrations and/or ratios of other metabolites in subjects; obtaining chemical structural data for the unknown metabolite; and using the information obtained to elucidate the identity of the unknown metabolite. |
| 申请公布号 |
US2014212872(A1) |
申请公布日期 |
2014.07.31 |
| 申请号 |
US201214128107 |
申请日期 |
2012.06.21 |
| 申请人 |
Milburn Michael;Kastenmueller Gabriele;Krumsiek Jan;Suhre Karsten |
发明人 |
Milburn Michael;Kastenmueller Gabriele;Krumsiek Jan;Suhre Karsten |
| 分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of elucidating the identity of an unknown metabolite, comprising:
(a) measuring amounts of known and unknown metabolites in subjects; (b) associating an unknown metabolite with a specific gene from a gene association study; (c) determining a protein associated with the specific gene and analyzing information for the protein; (d) associating the unknown metabolite with concentrations and/or ratios of other metabolites in the subjects using a partial correlation network; (e) obtaining chemical structural data for the unknown metabolite; and (f) deriving from the information obtained from steps (a) through (e) the identity of the unknown metabolite. |
| 地址 |
Cary NC US |
