Materials and Methods Useful to Induce Vacuolization, Cell Death, or a Combination Thereof

摘要

The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.

主权项

1. A compound comprising the structural formula of Formula VIIB: wherein:
O is attached at any one of positions 4, 5, 6, or 7;R is alkyl having from 1 to 6 carbon atoms either linear or branched;R1 is either:
alkyl having 2 carbon atoms further substituted at its terminus with a (CO)O-alkyl, (CO)O-aryl, or (CO)O-aralkyl moiety, oralkyl having 3 to 6 carbon atoms either linear or branched, aryl, heteroaryl, aralkyl, or heteroaralkyl having from 6 to 12 carbon atoms; andAr is aryl or heteroaryl; and pharmaceutically acceptable salts, hydrates, and optical isomers thereof.