发明名称 |
Compositions for Treatment of Attention Deficit Hyperactivity Disorder |
摘要 |
Therapeutic compositions and methods for treatment of attention deficit disorder (ADD) or attention deficit hyperactivity disorder (ADHD) include dosage forms that deliver a therapeutic amount of active drug in a delayed and controlled release formulation. The dosage form can be administered at night and drug release is delayed for from 4 to 6 hours or longer, followed by an ascending release rate. |
申请公布号 |
US2014212483(A1) |
申请公布日期 |
2014.07.31 |
申请号 |
US201414230053 |
申请日期 |
2014.03.31 |
申请人 |
Ironshore Pharmaceuticals & Development, Inc. |
发明人 |
Lickrish David;Zhang Feng |
分类号 |
A61K9/48;A61K31/4458 |
主分类号 |
A61K9/48 |
代理机构 |
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代理人 |
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主权项 |
1. A solid, oral pharmaceutical composition comprising a plurality of particles, each comprising:
a core comprising methylphenidate or a pharmaceutical salt thereof and at least one pharmaceutically acceptable excipient; a sustained release layer enclosing the core; and a delayed release layer enclosing the sustained release layer, wherein when the composition is orally administered to a human subject, there is a lag period of at least 5 hours during which the plasma concentration of methylphenidate or a pharmaceutical salt thereof is less than 10% of the maximum concentration (Cmax) and wherein the time to Cmax (Tmax) is between 12 and 19 hours after administration. |
地址 |
Camana Bay KY |