<p>The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders.</p>
申请公布号
SG11201403222U(A)
申请公布日期
2014.07.30
申请号
SG11201403222U
申请日期
2013.01.30
申请人
REGENERON PHARMACEUTICALS, INC.
发明人
MACDONALD, LYNN;GAO, MIN;MORRA, MARC., R.;ALESSANDRI-HABER, NICOLE, M.;LACROIX-FRALISH, MICHAEL, L.