发明名称 |
MODIFIED GRAM POSITIVE BACTERIA AND USES THEREOF |
摘要 |
The present invention relates to gram positive bacteria with increased stress resistance and/or improved storage characteristics. In particular, the invention relates to gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack cellobiose-specific PTS system IIC component (PtcC) activity. The gram positive bacterium may further lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof. |
申请公布号 |
EP2758513(A1) |
申请公布日期 |
2014.07.30 |
申请号 |
EP20120773253 |
申请日期 |
2012.09.21 |
申请人 |
ACTOGENIX N.V. |
发明人 |
STEIDLER, LOTHAR;VAN HUYNEGEM, KAROLIEN;VANDENBROUCKE, KLAAS |
分类号 |
C12N1/04;A61K39/09 |
主分类号 |
C12N1/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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