Compositions and methods for treatment of non-hodgkins lymphoma

摘要

The present invention provides recombinant peptides comprising a B cell receptor (BCR) or a fragment thereof, nucleotide molecules encoding same, and vaccines and vectors comprising same; and methods of treating, inducing an immune response against, inducing a regression of, and suppressing a formation of a lymphoma, comprising administering same. The present invention also provides methods of inducing a humoral immune response in an animal against an antigen, comprising administering to the animal a fusion peptide comprising an LLO protein or fragment thereof fused to the antigen.

主权项

1. A fusion peptide comprising a listeriolysin O (LLO) protein or a fragment thereof and an antigen, wherein said LLO protein or fragment thereof is chemically conjugated to said antigen, wherein said chemical conjugation to said antigen enables both a cell-mediated response and a humoral response to said antigen, wherein said antigen is a fragment of a B cell receptor (BCR), and wherein said fragment comprises the idiotype of said BCR.