发明名称 |
A process for the preparation of alpha-n-acyl alpha' chloroketones |
摘要 |
The present invention relates to a process for the preparation of alpha' chloroketones, such as 4-phenyl-3-t-butyloxy-carbonylamino)-2-keto-1-chlorobutane by reacting certain aryl amino acid esters, e.g. N-(2-t-butoxycarbonyl)-L-phenylalanine-4-nitrophenyl ester, with a sulfur ylide compound to form the corresponding keto ylide compound which is then treated with a source of chloride and an organic acid. |
申请公布号 |
HU229795(B1) |
申请公布日期 |
2014.07.28 |
申请号 |
HU20030002344 |
申请日期 |
2001.07.20 |
申请人 |
BRISTOL-MYERS SQUIBB HOLDINGS IRELAND BAAR |
发明人 |
KRONENTHAL DAVID YARDLEY;SCHWINDEN MARK D. NEWTON |
分类号 |
C07C271/18;C07D303/46;C07C221/00;C07C269/06;C07C271/16;C07C315/04;C07C317/28;C07D303/36 |
主分类号 |
C07C271/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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