| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: claimed invention relates to the field of biotechnology and virology. Described is a chimeric pestivirus, where the said chimeric pestivirus includes the cattle diarrhea virus, which does not express its homologous Eprotein. The said chimeric pestivirus expresses a heterologous Eprotein, originating from the other pestivirus, or a natural, synthetic or genetic version of the said heterologous Eprotein. Also described are methods and sets for treatment or prevention of propagation of the infection, caused by the cattle diarrhea virus, as well as methods for a differentiation between the vaccinated animals and the animals, infected with the virus of a wild type.EFFECT: invention can be used as immunogenic compositions and vaccines in animal breeding.13 cl, 4 tbl, 5 ex |
