POLYSACCHARIDE AND PROTEIN-POLYSACCHARIDE CROSS-LINKED HYDROGELS FOR SOFT TISSUE AUGMENTATION

摘要

Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and optionally including proteins. In one aspect, hyaluronic acid-based compositions described herein include zero-length cross-linked moieties and optionally at least one active agent. The present hyaluronic acid-based compositions have enhanced flow characteristics, hardness, and persistence compared to known hyaluronic acid-based compositions. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.

主权项

1. A method for making hydrogel for soft tissue augmentation comprising:
providing at least one cross-linkable biocompatible polymer; dissolving said at least one cross-linkable biocompatible polymer in a buffered solution wherein said buffered solution maintains a pH from approximately 6.0 to 8.0; adding at least one zero-length cross-linking agent to said buffered solution to form a reaction mixture; and allowing said reaction mixture to stand for a time appropriate to form a hydrogel suitable for soft tissue augmentation.