发明名称 |
L-ornithine phenyl acetate and methods of making thereof |
摘要 |
Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate. |
申请公布号 |
US8785498(B2) |
申请公布日期 |
2014.07.22 |
申请号 |
US201313937107 |
申请日期 |
2013.07.08 |
申请人 |
Ocera Therapeutics, Inc. |
发明人 |
Anderson Keith;Behling Jim;Dougan Christine Henderson;Watt Stephen William;Manini Peter;Figini Attilia |
分类号 |
C07C57/32;A61K31/205 |
主分类号 |
C07C57/32 |
代理机构 |
Knobbe Martens Olson & Bear LLP |
代理人 |
Knobbe Martens Olson & Bear LLP |
主权项 |
1. A composition comprising a crystalline form of L-ornithine phenyl acetate, wherein said crystalline form exhibits an X-ray powder diffraction pattern comprising at least three characteristic peaks, wherein said characteristic peaks are selected from the group consisting of approximately 4.9°, 13.2°, 17.4°, 20.8° and 24.4° 2θ. |
地址 |
Palto Alto CA US |