Biobeneficial coating compositions and methods of making and using thereof

摘要

A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, an implantable device coated with the composition, and a method of treating a disorder are provided.

主权项

1. A method of treating a disorder in a subject by implanting in the subject an implantable device, wherein the implantable device comprising a coating which comprises a composition, wherein the composition comprises
(1) a first block copolymer having the following structure: wherein m and n are positive integers, and (2) a second block copolymer comprising
(i) a biobeneficial component selected from the group consisting of sodium hyaluronate, hyaluronic acid, heparin, and 4-amino-2,2,6,6-tetramethylpiperidine-1-oxide; and(ii) a component miscible with the first block copolymer selected from the group consisting of polystyrene-polyisobutylene-polystyrene block copolymer (SIS), polystyrene, and polyisobutylene.