| 摘要 |
Methods can prepare tissue engineering scaffolds that include a plurality of biocompatible core/shell microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of pores for growing cells. The biocompatible microspheres can include first and second sets of microspheres. The first set of microspheres can have a first characteristic, and a first predetermined spatial distribution with respect to the three-dimensional matrix. The second set of microspheres can have a second characteristic that is different from the first characteristic, and a second predetermined spatial distribution that is different from the first predetermined spatial distribution with respect to the three-dimensional matrix. The first and second characteristics can selected a composition, polymer, particle size, particle size distribution, type of bioactive agent, type of bioactive agent combination, bioactive agent concentration, amount of bioactive agent, rate of bioactive agent release, mechanical strength, flexibility, rigidity, color, radiotranslucency, radiopaqueness, or the like. |
| 主权项 |
1. A biocompatible implant configured as a tissue engineering scaffold comprising:
a plurality of biocompatible particles linked together so as to form a three-dimensional matrix having a plurality of pores defined by and disposed between the particles, said plurality of particles having a surface area sufficient for growing cells within the plurality of pores, said plurality of biocompatible particles comprising:
a first set of particles having a first characteristic, the first set of particles having a first predetermined spatial distribution with respect to a first end of the three-dimensional matrix, the first set of particles having a core and one or more polymeric shells, the core and polymeric shells being different materials; anda second set of particles having a second characteristic that is different from the first characteristic, the second set of particles having a second predetermined spatial distribution with respect to a second end of the three-dimensional matrix and that is different from the first predetermined spatial distribution with respect to the three-dimensional matrix. |
