发明名称 |
PROCESS FOR THE CYCLODEHYDRATION OF DIOLS AND USE THEREOF FOR THE MANUFACTURING OF AMBRAFURAN AND OTHER CYCLOETHER DERIVATIVES |
摘要 |
A process for manufacturing tetrahydrofuran, tetrahydropyran and, more generally, cycloether derivatives through the cyclodehydration of 1,4- or 1,5-diols. More specifically, the process of the invention involves (i) the stereoselective cyclodehydration in water of 1,4- or 1,5-diols including at least one chiral tertiary alcohol functional group with retention of the initial chirality, and/or (ii) the cyclodehydration in water of 1,4- or 1,5-diols, said diols being non-miscible with and/or non-soluble in water, into corresponding cycloether derivatives, by bringing the reaction mixture to high temperature water (HTW) conditions and/or by mixing the aqueous reaction mixture with a solid catalyst, such as for example a smectite clay. Also, the use of the process for manufacturing ambrafuran, especially (−)-ambrafuran and other cycloether derivatives. |
申请公布号 |
US2014199741(A1) |
申请公布日期 |
2014.07.17 |
申请号 |
US201214232464 |
申请日期 |
2012.07.13 |
申请人 |
Carey Charles |
发明人 |
Carey Charles |
分类号 |
C07D307/92;C12P7/22;C07D311/70;C07D311/58;B01J19/24 |
主分类号 |
C07D307/92 |
代理机构 |
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代理人 |
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主权项 |
1. A process for the manufacturing of a cycloether derivative comprising
(i) stereoselective cyclodehydration in water of 1,4- or 1,5-diols comprising at least one chiral tertiary alcohol functional group with retention of the initial chirality, and/or (ii) cyclodehydration in water of 1,4- or 1,5-diols, said diols being non-miscible with and/or non-soluble in water,into corresponding cycloether derivatives, said process comprising:
bringing a reaction mixture of (i) water and 1,4- or 1,5-diols comprising at least one chiral tertiary alcohol functional group with retention of the initial chirality and/or (ii) water and 1,4- or 1,5-diols, said diols being non-miscible with and/or non-soluble in water to high temperature water (HTW) conditions and/or mixing a reaction mixture of (i) water and 1,4- or 1,5-diols comprising at least one chiral tertiary alcohol functional group with retention of the initial chirality and/or (ii) water and 1,4- or 1,5-diols, said diols being non-miscible with and/or non-soluble in water with a solid catalyst. |
地址 |
Paris FR |