NOUVEAU PROCEDE DE PREPARATION DE DERIVES (POLY) AMINOALKYLAMINOACETAMIDE D'EPIPODOPHYLLOTOXINE,UTILES POUR LEURS APPLICATIONS EN THERAPEUTIQUE COMME AGENT ANTICANCEREUX.

摘要

The present invention relates to a new process for the preparation of (poly)aminoalkylaminoacetamide derivatives of epipodophyllotoxin and salts thereof, characterized in that it comprises a step of peptide coupling of 4-amino-4'-demethylepipodophyllotoxin with an amine-containing reactant having protecting groups.