Method for reducing expression of downregulated in renal cell carcinoma in malignant gliomas

摘要

The present invention relates to novel compositions and therapeutic methods for the treatment of cancer, in particular malignant glioma. The compositions include antisense oligonucleotides or RNAs or vectors encoding them which reduce expression of downregulated in renal cell carcinoma (DRR) in tumor cells, and inhibit malignant glioma cell invasion.

主权项

1. An antisense oligonucleotide or RNA for reducing the expression of downregulated in renal cell carcinoma (DRR) in tumor cells, comprising the nucleotide sequence:
5′ A-A-T-G-T-C-T-G-C-C-C-G-C-T-C-C-C-T-C-T 3′ (SEQ ID NO: 16)wherein said antisense oligonucleotide or RNA comprises phosphorothioate internucleotide linkages.