PROTECTION OF CELLS FROM ALU-RNA-INDUCED DEGENERATION AND INHIBITORS FOR PROTECTING CELLS

摘要

A method of protecting a cell includes inhibiting an inflammasome, MyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NFκB of the cell. Administering an inhibitor of MyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NFκB can protect the cell from Alu-RNA-induced degeneration. Protecting a cell, such as an retinal pigment epithelium (RPE), can be therapeutically useful in the context of age-related macular degeneration and geographic atrophy.

主权项

1. A method of protecting a cell, comprising: inhibiting one or more of an inflammasome of the cell; MyD88 of the cell; IL-18 of the cell; VDAC1 of the cell; VDAC2 of the cell; caspase-8 of the cell; and NFκB of the cell.