| 发明名称 |
ANIMAL MODELS AND THERAPEUTIC MOLECULES |
| 摘要 |
The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. |
| 申请公布号 |
US2014182003(A1) |
申请公布日期 |
2014.06.26 |
| 申请号 |
US201314056434 |
申请日期 |
2013.10.17 |
| 申请人 |
Kymab Limited |
发明人 |
Bradley Allan;Lee E-Chiang;Liang Qi;Wang Wei;Legent Anais;Kirby Ian |
| 分类号 |
A01K67/027 |
主分类号 |
A01K67/027 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A host rodent whose genome comprises a chimeric immunoglobulin (Ig) locus, said chimeric Ig locus comprising human Ig locus DNA and host Ig locus DNA, said host Ig locus DNA comprising a host Ig upstream region and a host Ig downstream region,
said host Ig upstream region comprising a host J region comprising a host J segment and said host Ig downstream region comprising a host Ig constant (C) region segment DNA comprising a host C segment, wherein said human Ig locus DNA is positioned downstream of said host Ig J region and upstream of said host Ig C region, said human Ig locus DNA comprising one 10 or more human Ig variable (V) segments and one or more human Ig joining (J) segments. |
| 地址 |
Cambridge GB |
