发明名称 |
TREATMENT OF PHARMACOLOGICAL-INDUCED HYPOCHLORHYDRIA |
摘要 |
Changes in gastric pH due to oral co-administration of acid-reducing agents, such as proton pump inhibitors, and oncology drugs can have a marked impact on the absorption and oral bioavailability of the oncology drug if the pH decreases the maximal absorbable dose. Moreover, there is a potential for specific drug-drug interactions between some of the acid-reducing agents and these drugs. Methods are described for treating patients on gastric acid-reducing therapy with orally-administered PI3K inhibitor compound GDC-0941. Treatment with a re-acidification compound during treatment with GDC-0941 improves bioavailability of GDC-0941. |
申请公布号 |
KR20140074995(A) |
申请公布日期 |
2014.06.18 |
申请号 |
KR20147012375 |
申请日期 |
2012.10.12 |
申请人 |
GENENTECH, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
BENET LESLIE Z.;DALZIEL GENA;DEAN BRIAN;DRESSER MARK;FRYMOYER ADAM;HOLDEN SCOTT;JIN JIN;WARE JOSEPH A. |
分类号 |
A61K31/205;A61K31/416;A61K31/497;A61K31/519;A61K31/5377;A61P1/00 |
主分类号 |
A61K31/205 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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