| 发明名称 | Method of treating hepatitis C virus | ||
| 摘要 | A method of treating or inhibiting hepatitic C virus (HCV). The method comprises administering an effective amount of at least one pokeweed antiviral protein (PAP) mutant alone or in combination with other anti-HCV agents. | ||
| 申请公布号 | US8753642(B2) | 申请公布日期 | 2014.06.17 |
| 申请号 | US200812449076 | 申请日期 | 2008.01.18 |
| 申请人 | Rutgers, The State University of New Jersey | 发明人 | Di Rong;Tumer Nilgun E. |
| 分类号 | C07K14/00 | 主分类号 | C07K14/00 |
| 代理机构 | Dann, Dorfman, Herrell & Skillman | 代理人 | Dann, Dorfman, Herrell & Skillman ;Rigaut Kathleen D. |
| 主权项 | 1. A composition of matter comprising a non-cytotoxic PAP mutant that binds HCV IRES and inhibits translation of HCV RNA, conjugated to a hepatocyte receptor specific ligand wherein said mutant is SEQ ID NO: 1 having at least one amino acid substitution selected from the group consisting of N70A, L71R, V73E, G75D, Y123A, E176V, and said hepatocyte specific ligand is selected from the group consisting of ricin B, Shiga-like B subunit and asialoglycoprotein. | ||
| 地址 | New Brunswick NJ US | ||