| 摘要 |
<p>A preparation method of anhydrous dasatinib in the polymorph form N-6 of formula (I), characterized by the following reflections in an X-ray powder pattern, measured using the CuKa radiation: 6.8; 12.3; 13.2; 13.8; 16.7; 21.0; 24.3 and 24,8 ± 0,2° 2-theta, said method consisting of the following steps: a) preparation and isolation of dasatinib in the form of a solvate or in unsolvated form; b) dissolution of dasatinib obtained in step a) in a crystallization solvent selected from lower alcohols; c) addition of a co-solvent selected from acetonitrile and propionitrile, or a mixture thereof, and isolation of crystalline dasatinib in the polymorph form N-6.</p> |
