| 发明名称 |
MIRNA MOLECULE FOR NEGATIVELY REGULATING TYPE I INTERFERON PATHWAY AND USE THEREOF |
| 摘要 |
<p>Disclosed are a miRNA molecule for negatively regulating a type I interferon pathway and uses thereof, discovering that Has-miR-127-3p is closely related to systemic lupus erythematosus, and also verifying the target pathway of the miRNA, finding that the Has-miR-127-3p can inhibit the type I interferon pathway, therefore the miRNA can be used to prevent and treat the diseases related to the abnormal activation of the type I interferon pathway.</p> |
| 申请公布号 |
WO2014086243(A1) |
申请公布日期 |
2014.06.12 |
| 申请号 |
WO2013CN88018 |
申请日期 |
2013.11.28 |
| 申请人 |
SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES |
发明人 |
SHEN, NAN;QU, BO;HAN, XIAO;LIANG, DONG |
| 分类号 |
A61K48/00;A61K31/7105;A61P3/10;A61P19/02;A61P21/00;A61P25/00;A61P25/28;A61P29/00;A61P37/02;C12Q1/68;G01N33/53 |
主分类号 |
A61K48/00 |
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