发明名称 |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
摘要 |
<p>The present invention relates to a novel class of 4-carboxybenzylamino derivatives. The 4-carboxybenzylamino compounds can be used to treat cancer. The 4-carboxybenzylamino compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the 4-carboxybenzylamino derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the 4-carboxybenzylamino derivatives in vivo.</p> |
申请公布号 |
AU2008269154(B2) |
申请公布日期 |
2014.06.12 |
申请号 |
AU20080269154 |
申请日期 |
2008.06.24 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
HARRINGTON, PAUL;TEMPEST, PAUL;WITTER, DAVID;KATTAR, SOLOMON;MILLER, THOMAS A.;WILSON, KEVIN J.;STANTON, MATTHEW |
分类号 |
C07C237/40;A01N47/28;A61K31/17 |
主分类号 |
C07C237/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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