发明名称 NOVEL [F-18]-LABELLED L-GLUTAMIC ACID AND L-GLUTAMINE DERIVATIVES (I), THEIR USE AND PROCESSES FOR THEIR PREPARATION
摘要 What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.
申请公布号 US2014154183(A1) 申请公布日期 2014.06.05
申请号 US201414173371 申请日期 2014.02.05
申请人 BAYER SCHERING PHARMA AG 发明人 FRIEBE Matthias;SCHMITT-WILLICH Heribert;BERNDT Matthias;DINKELBORG Ludger;KOGLIN Norman;GRAHAM Keith
分类号 A61K49/04;C07C229/24;C07C271/22;C07C269/06;C07D207/16;C07C231/12;C07C227/16;C07C237/06;C07C309/66 主分类号 A61K49/04
代理机构 代理人
主权项 1) Compounds of the general formula I in which A represents a) hydroxyl,b) branched or straight-chain C1-C5 alkoxy,c) branched or straight-chain hydroxy C1-C5 alkoxy,d) branched or straight-chain O—C1-C5 alkyl-(O—C1-C4 alkyl)n-O—C1-C4 alkyl,e) N(C1-C5 alkyl)2,f) NH2,g) N(H)-L,h) O-L ori) O—Z, G represents a) hydroxyl,b) O—Z,b) branched or straight-chain O—C1-C5 alkyl,c) branched or straight-chain O—C2-C5 alkenyl,d) branched or straight-chain O—C1-C5 alkyl-(O—C1-C4 alkyl)n-O—C1-C4 alkyl,e) branched or straight-chain O—C2-C5 alkynyl orf) triphenylmethoxy, R1 and R2 represent a) hydrogen,b) branched or straight-chain 18F—C1-C5 alkoxy,c) branched or straight-chain 18F—C1-C5 alkyl,d) branched or straight-chain 18F—C2-C5 alkenyl,e) branched or straight-chain 18F—C2-C5 alkynyl,f) hydroxyl,g) branched or straight-chain C1-C5 alkyl orh) branched or straight-chain C1-C5 alkoxy, alkyl being optionally interrupted by one or more O, S or N,with the proviso that one of the substituents R1 or R2 contains exactly one 18F isotope and the respective other substituent contains no 18F isotope, with the proviso that R1 is not hydrogen, L represents a) branched or straight-chain C1-C5 alkyl,b) branched or straight-chain C2-C5 alkenyl,c) branched or straight-chain C1-C5 alkyl-(O-C1-C4 alkyl)n-O—C1-C4 alkyl ord) branched or straight-chain C2-C5 alkynyl, Z represents a metal cation equivalent, and where n=0, 1, 2 or 3.
地址 Berlin DE