METHOD FOR IDENTIFYING NEUROPROTECTIVE COMPOUNDS AND/OR NEUROREGENERATION STIMULATORS BY FRACTIONAL ANISOTROPY MEASUREMENTS BY DIFFUSION-BASED MRI SCANNING

摘要

The present invention relates to a method for monitoring the effectiveness of a treatment on neuroprotection and to a method for identifying candidate molecules that are neuroprotectors and/or neuronal growth stimulators. The present invention can be used, in particular, in the field of pharmaceutics, in the field of scientific research and in the field of clinical trials and validation of therapeutic substances.

主权项

1. A method for monitoring the effectiveness of a treatment on neuroprotection comprising:
a) measurement of the fractional anisotropy FA1 in at least one region of interest of the brain on an image obtained by Magnetic Resonance Imaging (MRI) of the brain of a patient before said treatment, b) measurement of the fractional anisotropy FA2 of said at least one region of interest of the brain on an MRI imaging of the brain of said patient after said treatment, c) comparison of the fractional anisotropy values and calculation of a score (S) according to the following formula:
S=FA2/FA1,a value of S greater than 1.08 indicating that the treatment is a neuroprotective and/or neural growth stimulator treatment.