发明名称 NOVEL SUBSTITUTED BIPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS
摘要 The present invention relates to novel substituted 2,4′- and 3,4′-bipyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
申请公布号 US2014155401(A1) 申请公布日期 2014.06.05
申请号 US201414175719 申请日期 2014.02.07
申请人 BAYER INTELLECTUAL PROPERTY GMBH 发明人 NELL Peter;Hübsch Walter;ALBRECHT-KÜPPER Barbara;KELDENICH Jörg;KNORR Andreas
分类号 C07D417/14;A61K45/06;C07D401/14;A61K31/5377;A61K31/501;C07D409/14;C07D413/14;A61K31/444;A61K31/506 主分类号 C07D417/14
代理机构 代理人
主权项 1. A compound of formula (I)wherein one of the two ring members X and Y represents N and the other represents C—R6, where R6 represents hydrogen or (C1-C4)-alkyl, Z represents N—R7 or O, where R7 represents hydrogen or (C1-C4)-alkyl which may be substituted by hydroxyl or (C1-C4)-alkoxy, R1 and R2 are identical or different and independently of one another represent hydrogen or (C1-C6)-alkyl which may be mono- or disubstituted by identical or different substituents from a group consisting of hydroxyl, (C1-C4)-alkoxy, amino, mono-(C1-C4)-alkylamino, di-(C1-C4)-alkylamino, carboxyl, (C1-C4)-alkoxycarbonyl and a 4- to 7-membered heterocycle, where the heterocycle mentioned contains one or two ring heteroatoms from the group consisting of N, O and S and for its part may be mono- or disubstituted by identical or different substituents from the group consisting of (C1-C4)-alkyl, hydroxyl, oxo and (C1-C4)-alkoxy, or R1 and R2 together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocycle which may contain a further ring heteroatom from the group consisting of N, O and S and which may be mono- or disubstituted by identical or different substituents from the group consisting of (C1-C4)-alkyl, hydroxyl, oxo and (C1-C4)-alkoxy, R3 represents hydrogen or (C1-C6)-alkyl which may be mono- or disubstituted by identical or different substituents from the group consisting of (C3-C6)-cycloalkyl, oxo, hydroxyl, (C1-C4)-alkoxy, carboxyl, amino, mono-(C1-C4)-alkylamino and di-(C1-C4)-alkylamino, or represents (C4-C6)-cycloalkyl, where the cycloalkyl radicals mentioned for their part may be substituted up to two times by identical or different substituents from the group consisting of (C1-C4)-alkyl, hydroxyl, oxo and (C1-C4)-alkoxy and where in these cycloalkyl radicals a ring CH2-group may be replaced by an oxygen atom, R4 represents hydrogen, halogen, (C1-C4)-alkyl or (C1-C4)-alkoxy, where alkyl and alkoxy may each be substituted up to three times by fluorine, and R5 represents 5 to 10-membered heteroaryl having up to three ring heteroatoms from the group consisting of N, O and S, which may in each case (i) be mono- or disubstituted by identical or different substituents from the group consisting of halogen, nitro, cyano, (C1-C6)-alkyl, phenyl, hydroxyl, (C1-C6)-alkoxy, amino, mono-(C1-C6)-alkylamino, mono-(C2-C6)-alkenylamino and di-(C1-C6)-alkylaminoand/or(ii) be substituted by pyrrolidino, piperidino, morpholino, piperazino, N′—(C1-C4)-alkylpiperazino or a group of the formula -L-R8, where L represents a bond, NH or OandR8 represents phenyl or 5- or 6-membered heteroaryl having up to three ring heteroatoms from the group consisting of N, O and S, each of which may be mono- to trisubstituted by identical or different substituents from the group consisting of halogen, nitro, cyano, (C1-C6)-alkyl, trifluoromethyl, hydroxyl, (C1-C6)-alkoxy, difluoromethoxy, trifluoromethoxy, amino, mono-(C1-C6)-alkylamino, di-(C1-C6)-alkylamino, (C1-C6)-alkoxycarbonyl and carboxyl,or a salt thereof.
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