Reflective non-contact ocular pulse analyzer for clinical diagnosis of eye and cerebrovascular disease

摘要

An instrument has been designed to study the pulsatile motion of the eye by analysis of a beam of light reflected from the corneal surface. A laser light beam probe of small spot size and low divergence strikes the cornea apex and the reflected movement is recorded by a sensor. Analysis of the beam movement reveals the energy in the eye pulse without the necessity of physically touching the eye. The value of the intraocular pressure is determined from the calculated power spectrum. The sensitivity, accuracy and efficiency of the light beam makes possible studying both eyes concurrently and comparison of the pulse parameters of onset, amplitude and duration reveals any delay in circulation to an eye.

主权项

1. A method for evaluating eye disease by measuring eye surface movement during an ocular pulse, said method comprising:
identifying a blood pulse by sphygmomanometer on an arm, electrocardiography or ultrasonography; using a laser light source to form a coherent gaussian, sub-millimeter diameter, low divergence probe beam that strikes the central cornea of the eye at a high angle of incidence; using a processor synchronizing the beam with a blood pulse selected with a sphygmometer, electrocardiogram or ultrasonogram and record eye front surface movement; magnifying a received reflection from the cornea of the beam that strikes a CCD camera sensor array; calculating with a processor from the received beam reflected a plurality of parameters, including at least two from the group consisting of an ocular pulse amplitude waveform, a power spectra, a zero frequency amplitude of power spectrum, and non-zero frequency amplitudes, wherein the zero frequency amplitude of the power spectrum is a measure of energy in a mean intraocular pressure, and non-zero amplitudes are a measure of pressure changes during the ocular pulse that are indicative of eye disease.