PREPARATION OF PRECURSORS FOR LEUKOTRIENE ANTAGONISTS

摘要

The present invention relates to an improved process for the preparation of a compound having formula (I). The compound having formula (I) is the backbone diol precursor/intermediate used to produce montelukast sodium. Montelukast sodium is a leukotriene antagonist and is a useful agent in the treatment of asthma as well as other conditions mediated by leukotrienes, such as inflammation and allergies, e.g. allergic rhinitis.