MULTI-DOSE VACCINATION REGIMEN WITHOUT USE OF ADJUVANT

摘要

PROBLEM TO BE SOLVED: To provide a multi-dose vaccination regimen without the use of adjuvant.SOLUTION: An influenza vaccine is administered by a multi-dose regimen, in which (i) a first dose is administered with an adjuvant and (ii) a later dose is administered either without an adjuvant or with a different adjuvant. Thus the invention provides the benefits of a two-dose regimen without also doubling the supply need for a given adjuvant. The invention also provides a kit comprising: (i) a first influenza virus vaccine in combination with a first adjuvant; and (ii) a second influenza virus vaccine without that adjuvant.