发明名称 |
BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PEDIATRIC CHOLESTATIC LIVER DISEASES |
摘要 |
Provided herein are pediatric dosage forms for use in the treatment of a pediatric cholestatic liver disease by non-systemically administering to an individual in need thereof a therapeutically effective amount of the pediatric dosage form comprising an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are said pediatric dosage form for use in the treatment of a pediatric liver disease, for use in decreasing the levels of serum bile acids or hepatic bile acids, for use in the treatment of pruritis, for use in reducing liver enzymes or bilirubin comprising non-systemically administering to an individual in need thereof a therapeutically effective amount of a pediatric formulation comprising an ASBTI or a pharmaceutically acceptable salt thereof. |
申请公布号 |
SG11201401849Q(A) |
申请公布日期 |
2014.05.29 |
申请号 |
SG11201401849Q |
申请日期 |
2012.10.26 |
申请人 |
LUMENA PHARMACEUTICALS, INC |
发明人 |
GEDULIN, BRONISLAVA;GREY, MICHAEL;O'DONNELL, NIALL |
分类号 |
A61K31/495;A61K31/41;A61K31/4965;A61K31/4985;A61K31/5377;A61P1/16 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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