发明名称 |
BONE TARGETED ALKALINE PHOSPHATASE, KITS AND METHODS OF USE THEREOF |
摘要 |
A bone targeted alkaline phosphatase comprising a polypeptide having the structure : Z-sALP-Y-spacer-X-Wn-V, wherein sALP is the extracellular domain of the alkaline phosphatase; wherein V is absent or is an amino acid sequence of at least one amino acid; X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Wn is a polyaspartate or a polyglutamate wherein n = 10 to 16. Kits and methods of use thereof. |
申请公布号 |
PT2368999(E) |
申请公布日期 |
2014.05.26 |
申请号 |
PT20110004496T |
申请日期 |
2008.05.12 |
申请人 |
ALEXION PHARMA HOLDING |
发明人 |
PHILIPPE CRINE;ISABELLE LEMIRE;THOMAS P. LOISEL;GUY BOILEAU;PIERRE LEONARD;ROBERT HEFT;HAL LANDY |
分类号 |
C12N15/55;A61K38/46;A61P19/08;C12N5/10;C12N9/16;C12N15/85 |
主分类号 |
C12N15/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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