发明名称 |
Compounds that enhance Atoh-1 expression |
摘要 |
This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g. a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation. |
申请公布号 |
EP2732819(A2) |
申请公布日期 |
2014.05.21 |
申请号 |
EP20130182379 |
申请日期 |
2009.02.09 |
申请人 |
MASSACHUSETTS EYE & EAR INFIRMARY;THE BRIGHAM AND WOMEN'S HOSPITAL |
发明人 |
EDGE, ALBERT;SEYB, KATHLEEN;GLICKSMAN, MARCIE;QIAO, LIXIN;CUNY, GREGORY D.;JEON, SANG-JUN |
分类号 |
A61K31/4245;A61P19/00;A61P27/00;A61P35/00 |
主分类号 |
A61K31/4245 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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