IMPROVED PROCESS FOR ISOLATION AND PURIFICATION OF RAPAMYCIN FROM FERMENTATION BROTH

摘要

The present invention relates to a novel process for the isolation of water insoluble macrolide antibiotic rapamycin from the fermentation broth through sequential steps of biomass separation, extraction with suitable solvents and concentration. The invention also relates to separating rapamycin from the concentrate containing a mixture of homologs, analogs or isomers thereof by using normal phase chromatography followed by purification.