| 摘要 |
According to the present invention, the aspects of increased frequency of generated mutations in hepatitis type B virus which infect a patient group with chronic hepatitis type B and a patient group whose chronic hepatitis type B progresses to hepatoma on the X gene and precore/core gene, are analyzed through various molecular genetic analysis methods. Then, markers for predicting hepatoma on the X gene and precore/core gene, independently concerned with the onset of the hepatoma, are derived. The present invention relates to a highly sensitive and highly specific analyzing method of hepatoma onset risk for a chronic patient of hepatitis type B and a method of predicting same by using a mutation pattern, that is, a mutation accumulating number and/or combination of the markers for predicting the hepatoma. |
