发明名称 |
ANTIBODY VARIANTS AND USES THEREOF |
摘要 |
Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved effector functions, such as CDC-response. |
申请公布号 |
EP2729170(A2) |
申请公布日期 |
2014.05.14 |
申请号 |
EP20120740092 |
申请日期 |
2012.07.06 |
申请人 |
GENMAB B.V. |
发明人 |
PARREN, PAUL;BEURSKENS, FRANK;DE JONG, ROB N.;LABRIJN, ARAN FRANK;SCHUURMAN, JANINE |
分类号 |
A61K39/395;A61P35/00;C07K16/00;C07K16/28;C07K16/36 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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