发明名称 |
METHOD FOR PRODUCING PYRIMIDODIAZEPINONE COMPOUND |
摘要 |
Provided is a method for producing a compound represented by formula (I) (wherein R1 and R2 may be the same or different and each represents a hydrogen atom or the like, and Z represents an optionally substituted aryl group or the like) or a salt thereof, or the like. The production method comprises: (i) a step wherein a compound represented by formula (II) (wherein R1 and R2 are as defined above, R3 represents a lower alkyl group, and X represents a halogen atom or the like) is reacted with a compound represented by formula (III) (wherein Z is as defined above) or a salt thereof in the presence of a base, thereby obtaining a compound represented by formula (IV) (wherein R1, R2, R3 and Z are as defined above) or a salt thereof; and (ii) a step wherein the compound represented by formula (IV) or a salt thereof is processed with an acid or a base, thereby obtaining a compound represented by formula (I). |
申请公布号 |
WO2014069626(A1) |
申请公布日期 |
2014.05.08 |
申请号 |
WO2013JP79698 |
申请日期 |
2013.11.01 |
申请人 |
KYOWA HAKKO KIRIN CO., LTD. |
发明人 |
NITTA, MARIKO;SAKAI, DAISUKE;MATSUMURA, TSUTOMU;ATAGO, TAKAYUKI;MATSUMIYA, SHIGEKI;HAGIHARA, KOJI |
分类号 |
C07D487/14;A61K31/5517;A61P17/04;A61P25/04;A61P29/00;A61P43/00;C07B61/00;C07D519/00 |
主分类号 |
C07D487/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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