发明名称 |
LXR AND FXR MODULATORS |
摘要 |
Compounds of the invention are disclosed, such as compounds of formulae LX-LXIV, and pharmaceutically acceptable salts, isomers, or prodrugs thereof, which are useful as modulators of the activity of liver X receptors (LXR) and Farnesoid X receptors (FXR), where R00, R200, R400, R500, J11, J21, G1, G21, and Q are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed. |
申请公布号 |
EP2121621(B1) |
申请公布日期 |
2014.05.07 |
申请号 |
EP20070865385 |
申请日期 |
2007.12.07 |
申请人 |
EXELIXIS PATENT COMPANY LLC |
发明人 |
BOREN, BRANT CLAYTON;BUSCH, BRETT B.;GU, XIAO-HUI;JAMMALAMADAKA, VASU;LU, SHAO-PO;MARTIN, RICHARD;MOHAN, RAJU;SCHWEIGER, EDWIN;STEVENS, WILLIAM C. JR.;WANG, TIE-LIN;XIE, YINONG;XU, WEI |
分类号 |
C07D233/90;A61K31/415;A61K31/4164;A61P3/10;C07D231/10 |
主分类号 |
C07D233/90 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|