发明名称 |
Modified tRNA containing unnatural base and use thereof |
摘要 |
In the method for introducing a noncanonical amino acid residue into a desired position in a protein, the structure of tRNA is so modified as to have improved affinity for aminoacyl-tRNA synthetase or improved specificity to aminoacyl-tRNA synthetase. An unnatural base is contained at any position in tRNA, whereby the efficiency of aminoacylation of the tRNA with a noncanonical amino acid can be improved. |
申请公布号 |
US8715984(B2) |
申请公布日期 |
2014.05.06 |
申请号 |
US20090866720 |
申请日期 |
2009.02.03 |
申请人 |
SEKINE SHUN-ICHI;FUKUNAGA RYUYA;YOKOYAMA SHIGEYUKI;HIRAO ICHIRO;HARADA YOKO;RIKEN |
发明人 |
SEKINE SHUN-ICHI;FUKUNAGA RYUYA;YOKOYAMA SHIGEYUKI;HIRAO ICHIRO;HARADA YOKO |
分类号 |
C12N9/00;C12P21/06 |
主分类号 |
C12N9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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