Compositions and methods for inhibiting expression of transthyretin

摘要

602404 Discloses a composition comprising a lipid formulation and a double-stranded ribonucleic acid (dsRNA) for inhibiting expression of transthyretin (TTR), wherein the dsRNA comprises a sense strand and an antisense strand, the antisense strand comprising the sequence AUGGAAUACUCUUGGUUAC and the sense strand comprising the sequence GUAACCAAGAGUAUUCCAU, wherein the dsRNA strand is between 19-24 nucleotides in lenth.